Meditation leads to freedom from incessant, nagging thoughts and worries, and to inner strength, peace of mind, a sense of bliss, and in its higher levels, to spiritual awakening and enlightenment. As you see, meditation is much more than a method for relaxing the body, as some people think.

Though it plays an important role in various religions and spiritual practices, it is actually a practice that is free from all religious connotations, and has always been practiced everywhere, from ancient times until the present day. There has always been the desire to go within, to find what is beyond the physical form, and to find the real spirit and the relation between mankind, the world and the creator.

There are many forms, techniques and traditions of meditation, which are practiced and followed for various reasons and aims, such as for gaining peace of mind, spiritual growth and spiritual awakening, as well as for relaxation, health, success, mental powers or the development of psychic abilities.

Meditation calms down the body and the mind, reduces stress and anxiety, normalizes the blood pressure and has a healing effect on the body. It improves the concentration power, sharpens the mind and strengthens the intuition. Its constant practice reduces the number of restless thoughts in the mind, brings peace of mind, happiness and bliss, and in its higher stages, enlightenment.

In order to obtain results it has to be practiced every day, at least once a day, twice better, for at least 15 minutes, though a beginner may start with only 10 minutes a day.

In a very general sense, there are two forms of meditation. One form requires that you focus the mind on some activity, such as the breathing process, a concrete object, mental image, a word or a thought, and there is what may be termed as “formless meditation”, in which you focus on the inner silence, inner self or on nothing at all. This form can only be practiced after one is well trained with the first form.

Here are a few tips and advice about meditation:

1. It is important to meditate every day.

2. A positive attitude, patience and an open mind are of great help.

3. Do not meditate when you are tired.

4. Find a place where you can be alone and undisturbed.

5. Sit in a comfortable position with the spine erect.

6. Take a few slow deep breaths.

7. Bring to your mind some pleasant memory, and enjoy thinking about it for a few moments.

8. Think for a few moments about the benefits of meditation, how it will strengthen your focus, calm down your mind and ease stress and tension.

9. Tell yourself that all thoughts will have to wait now, and that nothing is going to distract your mind.

10. Start meditating calmly, yet with focused attention. The more focused the attention is, the easier it is to ignore thoughts and other distractions.

An Ayurvedic Approach

Ayurveda describes a group of diseases called Prameha which when translated into English means “Obstinate Urinary Disease”. This group comprises of all conditions related to urinary system like excess urination, Diabetes etc.

There are 20 forms of Prameha diseases. Prameha can be further categorised into three groups based on the Dosha dominance:
Kapha Prameha: 10 forms
Pitta Prameha: 6 forms
Vata Prameha: 4 forms

Diabetes is predominantly a Kapha disorder where by the Agni function is diminished. This leads to low metabolic rate in the body and build up of sugar levels in the blood.

The term given for the Diabetes Mellitus in Sanskrit is – Madhumeha (Madhu: sweet; meha: to flow or urination)

Diabetes Insipidus falls under the category of Kapha Prameha where as Diabetes Mellitus falls under the category of Vata Prameha. Therefore it is believed that although Diabetes is dominantly a Kapha disorder it is also influenced by the activity of Vata  (and to some extent Pitta) in the body.

Ayurveda has very classically presented the causes of Diabetes in the following manner:
• Inactivity
• Excessive sleep
• Excessive use of yoghurt
• Meat soup of the domestic, aquatic and marshy animals
• Sweet food articles
• All other Kapha-promoting regimens

Ayurvedically, Diabetes can occur through two modes of pathogenesis:
• Avarana: Blockage of paths or channels in the body
• Dhatukshaya: depletion of Dhatus or tissues in the body

Blockage of paths: Increased Kapha Dosha or other tissues like fat or muscle cause the blockage of the channel. This can lead to maturity onset diabetes.

Dhatukshaya, where the tissues are depleted, can be categorized as juvenile diabetes.

“Ojas” is the essence of digestion and hence essence of life (it is also termed as an extract of all the Dhatus (body tissue), which gives strength (Bala) to the body mind and soul. Ojas helps to determine the physical, mental, sensory and all other functions. In diabetes mellitus this essence of life is lost from the body through excretion in the urine (hence Diabetes Mellitus is also called Ojomeha (Ojo: Ojas; meha: to flow or urination).

Symptoms:
Ayurveda talks about three main symptoms (Rupas) for Diabetes. They are:
• Polyuria
• Sweetness in urine
• Sweetness in the body

Other signs and symptoms of diabetes can be polydypsia (excess thirst), diarrhea, fever, burning sensation, general debility, indigestion, necrosis, carbuncles, inflammatory lesions, wasting of muscles, excess sleep, and sluggishness.
Diabetes tends to affect all the Dhatus (tissues in the body):
Rasa (plasma): hyperglycaemia
Rakta (blood): deteriorated quality of the blood cells with increased viscosity and therefore become fragile.
Mamsa (muscles): muscle wasting, necrosis
Medhas (fat): hypertrophy of adipose tissue
Asthi (bone): de-mineralization of bone tissue, reduced density
Majja (nervous tissue): degeneration of brain tissue
Shukra (reproductive tissue): loss of libido, transmission to next generation
Sira (arteries): atherosclerosis
Tvak (skin): necrosis, ulcers, carbuncles
Snayu (nerves): neuropathies
Treatment protocol:
Stimulating the digestive fire (Agni) is very important.

Juvenile Diabetes Mellitus:
People suffering from the juvenile form have to take insulin. But even with insulin administration, a person may be weak all the time and infection prone. The best approach for such cases is a combined treatment of insulin and Ayurvedic remedies (especially to prevent complications). Herbs widely used in such cases are Bhumiamalaki, Guduchi, along with a restricted diet which comprises of bitter and astringent foods.

If Dhatukshaya (depletion of Dhatus or tissues) is observed then limited amounts of nourishing foods are given.

If there is an autoimmune factor involved, Ama has to be treated first and then other lines of treatment are applied.

Maturity Onset Diabetes Mellitus:
The approach for this kind of diabetes depends on the phase of diagnosis.
1. Food restriction and dietary advice
2. Food restriction, dietary advice, Yoga exercises
3. Shodhana (Ayurvedic detoxification e.g. Panchakarma), dietary advice and Yoga exercises
4. Shodhana (Ayurvedic detoxification e.g. Panchakarma), dietary advice, Yoga exercises, Ayurvedic herbal preparations

If person is physically strong, all 5 actions of Panchakarma can be administered. If a person is physically weak, then Basti (enema treatment) is the best line of approach.

Food:
The foods that help to keep sugar levels in the blood under control are bitter, astringent foods. Barley, mung beans, bitter gourd are very good. A Kapha pacifying diet should be followed. Plenty of cooked green vegetables are beneficial. Seeds of any bitter plants or fruits are good.

Herbs:
Any herb with a bitter quality is helpful. Commonly used Ayurvedic herbs are:

Turmeric: One can take turmeric with ale vera juice for good results.

Neem (Azadirachta indica) has traditionally been used in Ayurveda to purify the blood and support the immune system. It helps to maintain healthy blood glucose levels.
Guggulu (Commiphora mukul) has been traditionally used in Ayurveda to gently detoxify the body and support proper nutrition by stimulating the body’s metabolism to improve digestion and eliminate waste products. It helps to remove excess sugar and fat from the body through its scraping actions.
Triphala with aloe vera juice of Amalaki juice is beneficial.

Other useful herbs are Guduchi, Gokshura, Arjuna, Punarnava.

Yoga:
Kapha pacifying Yoga exercises are good. One very useful Yoga position is Mayurasana (peacock position). Other positions are sun salutation, locust position, leg lifts and chest to knee positions. Alternate nostril breathing is a good Pranayama for Diabetes.

It is strongly recommended that you consult a qualified Ayurvedic practitioner before starting any detoxification process to eliminate Ama or taking Ayurvedic herbs for diabetes. The treatment protocol may change based on a person’s body constitution and disease.

by Dr. Dheeraj Malhotra, MD (Ayu)

Heavy metals: Are they really heavy on human body?

Ayurveda is knowledge about healthy prolongation of life (Ayu + Veda). Is it possible that the Spiritual Gurus who unveiled this treasure to the ailing humanity could have made this blunder and reduce the life of a person?

The answer is bold – NO.

Those who do not understand the viewpoint of Ayurveda and the ones who do not want to understand it says so.

Let’s see what exactly the definition of Heavy metals is?

Historically

There is no consensus on a scientifically valid definition of heavy metals!

There is a layman tendency, unsupported by the facts to assume that all the so called heavy metals and their compounds are highly toxic or have eco-toxic properties .Their is no basis in chemical or toxicological data. Thus the term heavy metal is both misleading and meaningless. (John H.duffus; Pure & Applied Chemistry.74i793-807)

In the earliest reference of Heavy metals, Bjerrume’s Inorganic Chemistry -1936, he defined “Heavy metals as metals having density greater than 4 gm/cm”. (It simply means any metal which is 4 times heavier than water should be called as heavy metal. Consider Silver is a heavy metal). However it was never used as a formal or official definition. This is because there is no relationship between the density and any reactive properties associated with metals, or any other element in the periodic table.

Later on it was redefined on the basis of gram atomic weight and if you call this an official one, both Magnesium and Potassium are classified as heavy metals. The confusion keeps on increasing, when you find that the most referred book on toxicology Casarretl and Doull’s toxicology never used the term Heavy Metal. Now you are confused as the rest of the medical faculty of the world lets find out the real truth.

All metals are present in the earth’s crust and enter our bodies continuously at low levels. It is a common mistake, based on fear and misinformation, to believe that a toxin has a linear toxic effect down to the lowest levels. All toxins have a safe threshold below which there is no toxicity. In fact, below a safe threshold toxicity disappears and there is no toxicity at all – and in some cases even benefit exists. Mercury is most widely used metal in Rasa-Shastra discipline of Ayurveda and to some extent most controversial also. Recent developments have highlighted the need to research whether it should be used at all. Let’s gather all the relevant scientific data and accept it as truth.

How Can Mercury Enter and Leave our Body?

A person can be exposed to mercury from breathing in contaminated air, from swallowing or eating contaminated water or food, or from having skin contact with mercury.  Not all forms of mercury easily enter your body, even if they come in contact with it; so it is important to know which form of mercury you have been exposed to, and by which route (air, food, or skin).

When you swallow small amounts of metallic mercury, for example, from a broken oral thermometer, virtually none (less than 0.01%) of the mercury will enter your body through the stomach or intestines, unless they are diseased. Even when large amount of metal mercury (a half of a tablespoon, about 204 grams) was swallowed by one person, very little entered the body.

What Happens to It in the Body?

Inhalation – 80% is absorbed.
Following ingestion, Absorption is

1. Less than 0.01% for metallic mercury,
2. Less than 10% for inorganic mercury (mercury used in Ayurvedic medicine),
3. More than 95% for organic mercury (methyl mercury).

Mercury can also be absorbed through the skin, but the amount is small compared to breathing or swallowing it. (The “true absorption” of a single oral dose of HgCl2 was calculated to be about 20% at two different dose levels).

Mercury in the Bloodstream

Methyl mercury (organic form) is the form of mercury most easily absorbed through the gastrointestinal tract (about 95% absorbed). After you eat fish or other foods that are contaminated with methyl mercury, the methyl mercury enters your bloodstream easily and goes rapidly to other parts of your body.  Only small amounts of methyl mercury enter the bloodstream directly through the skin, but other forms of organic mercury (in particular dimethyl mercury) can rapidly enter the body through the skin.

From Mother to Fetus

There is no clear evidence that exposure to mercury or inorganic mercury compounds has adverse effects on the developing fetus.  However exposure to organic mercury compounds can slow the growth of unborn baby and disrupt the nervous system.  Organic mercury can be transferred from blood to milk posing the risk to new-born baby. (Pregnant workers information leaflet for notification of pregnancy. Govt. of U.K.)

What is around us Cannot be Ignored

In the air we breathe,

(The five super thermal power plants in the Singrauli area, which supply 10 per cent of India’s power, are responsible for 16.85  percent or 10 tonnes per annum of total mercury pollution . . through power generation. “A typical 100-megawatt thermal . power plant can emit over 10 kg of mercury in a single year. . . About 200 metric tonnes of toxic mercury escapes from industrial. . Chimneys and effluents each year in India, “said Anil Gautam,. . People’s Science Institute (PSI), a Dehra Doon based research. . Organization.)

In the food we eat

(Growing research shows a clear relationship between. . fish (tuna etc), Dental amalgams (MERCURY +SILVER) and the presence of mercury in body organs. It also links mercury fillings to autism and Alzheimer’s. This is continuous source of mercury poisoning)

It is not possible to totally eliminate all exposure. The goal is to stay below a toxic threshold.

It is not true that there’s no “safe” level for mercury.

At what level does mercury become harmful?

The World Health Organization’s guidelines maintain that the lowest level that could possibly be harmful to humans is 5 parts per million (ppm). This level is based on scientific results from the 1960s that placed the level at which risk begins at 50 ppm for most people; WHO then applied a safety factor of 10, deciding that a level of 5 or less is safe for even the most vulnerable populations.

Now the University of Rochester team has conducted an extensive study in the Seychelles Islands of the most sensitive population — young children — where the average level is about 7 ppm, about 10 times the level of the U.S. population. The scientists found no harm from mercury at levels up to 15 ppm, nearly twice the average Seychelles level and about 20 times higher than the average U.S. level.  Despite those reports, hair analysis laboratories in the U.S. continue to report of toxicity at only 1 ppm.

Hair mercury is considered a valid test if properly performed. The recent Seychelles Island study showed that hair mercury below 15 g/g (mean 6.9 ppm, SD 4.5 ppm) did not cause any problems in pregnant mothers or their newborn infants, who were followed with extensive neurological testing for many years from birth onwards. The diet contained ocean fish 12 meals per week. The fish contained the same amount of methyl mercury as found elsewhere in the world.

Laboratory Reference Ranges
for Toxic Metals in Blood and Urine

Mercury

Random urine < 5 g/g creatinine (Not provoked with a chelator).
Occupational limit in urine of exposed workers < 35 g/g creatinine (Not provoked with a chelator)
Whole blood < 8.0 g/L
Occupational limit in exposed workers < 15.0 g/L.
Hair <15 g/g (g/g = ppm)
Environmental exposure: < 8.0 g/L, individuals consuming large quantities of seafood may have values as high as 200.0 g/L.
Occupational exposure: BEI: inorganic mercury (sampling time is end of shift at end of work week): <15.0 g/L1

Some Common Mistakes

Reference ranges for upper safe limits for metals, including mercury in urine, are often printed on laboratory report forms with ranges that apply only to urine collected without first giving a chelator. The safe upper limit on the report form will thus be much higher after a chelator. If proper procedures are followed, a large majority of people tested will be in the nontoxic range.

By provoking urine excretion with a chelator, metals in urine will always increase, by up to 1,000% or more, even if levels in the body are at quite safe and low levels. The result therefore, usually appears deceptively high. That type of report is meaningless and can frighten patients into thinking they are toxic when their levels are actually quite safe.

Methyl mercury and HgS was orally administrated to mice for five consecutive days.

The present study suggests that the insoluble HgS (the main constituent of a Chinese mineral drug, cinnabar, used as a sedative) can still be absorbed from gastrointestinal tract and distributed to various tissues including the brain.

As compared with methyl mercury, the total amount of HgS accumulated in the tissues ranging is about one five-thousandth of methyl mercury, which is well correlated with the biological activity of HgS reported previously.

(Tissue distribution of different mercurial compounds analyzed by the improved FI-CVAAS. Yen CC, Liu SH, Chen WK, Lin RH, Lin-Shiau SY. Institute of Toxicology, College of Medicine, National Taiwan University, Taipei.) PMID: 12166816 [PubMed - indexed for MEDLINE] HgS or cinnabar was administered orally (1.0 g/kg) to Hartley-strain guinea pigs once daily for 7 consecutive days. A battery of electrophysiological, biochemical, and histopathological examinations were performed.

Conclusion The increased Hg contents in the cerebellum following oral administration of HgS and cinnabar were responsible, at least in part, for the detrimental neurotoxic effect on the VOR (vestibular ocular reflex system).
Young YH, Chuu JJ, Liu SH, Lin-Shiau SY.

Neurotoxic mechanism of cinnabar and mercuric sulfide on the vestibulo-ocular reflex system of guinea pigs. Department of Otolaryngology, National Taiwan University Hospital, No. 1 Section 1, Jen-Ai Road, Taipei, Taiwan. PMID: 12011485 [PubMed - indexed for MEDLINE]

Purification of Ayurvedic Mercurial Preparations

From my personal scientific perspective these detoxifications do not have anything mystical or magical about them. All the described processes lead to the elimination of impurities through mechanical/chemical treatment of the mercury, which is then followed by a prolonged heat treatment. Sulphur is added through which process mostly the inert Compound is obtained.

Metals of Ayurveda behave differently than their counter parts in modern Medicine.

Phenomenon of Isomerism

Kajjali and Parpati have different actions o the body although both of them are black sulphide of mercury. The difference between them is them is the Sanskara (processing). The preparation of Kajjali does not involve heating while rasa-parpati is obtained after heating Kajjali.

Patients allergic to modern sulpha drugs do not show allergic reaction when Gandhaka Rasayana is given (the difference is processing, Ayurvedic Sulphur compounds are purified and prepared as per Ayurvedic texts). The daily dosage during an Ayurvedic treatment is about 30-40 mg of mercuric sulphide. This usually is given in combination with processed aconite (and together with the fruit of Terminalia chebula etc.)

It is believed that metals in Ayurvedic preparations exist in complex ionic redicular form due to unique heat processing and herbal treatment. e.g. Loha Bhasma does not give positive test by routine method of testing for iron i.e. with Sodium Carbonate, Potassium Sulpho cyanide and Potassium ferro cyanide. Nitric acid is required to get the positive result for the presence of iron .Nitric acid breaks the complex iron radicle in to a simpler radicle.

(One Tibetan Dschu-Mar 25 jewel-pill contains (depending on its origin) according to analysis between 10-50 mg Cinnabar which corresponds closely to the Ayurvedic prescriptions. With the use of atomic absorption spectrometry at Ulm University a project was undertaken to investigate Dschu-mar 25 pills from different origins: a wide variation in the concentration of mercury was thereby discovered One result of this analysis seems to be of special importance: it was not only the inert and therefore untoxic HgS (Cinnabar) which was discovered in Dschu-mar 25.

Some Facts

1. Inorganic mercury compounds like mercurous chloride and mercuric chloride are white powders and do not generally vaporize at room temperatures like elemental mercury will. If they are inhaled, they are not expected to enter your body as easily as inhaled metallic mercury vapor.

2. When inorganic mercury compounds are swallowed, generally less than 10% is absorbed through the intestinal tract ;( the WHO has set up Provisional Tolerable Weekly Intake (PTWI)  that allows 3.3 mg/kg of methyl mercury for tuna fish and shell fish) considering 1gm/kg is fed to rats which is very high dose when compared to use of mercury in Ayurvedic formulations which is 30-40mg /day in approximately 60 kg person comes out to be 0.5-0.6mg/kg. (As compared with methyl mercury, the total amount of HgS accumulated in the tissues ranging about one five-thousandth of methyl mercury) and dividing it by 5000 it comes out to be .0001 a difference of 0 .9999 mg/kg between the thinking pattern of ancient scholars and western scientists.

3. As per absorption principle inorganic mercury absorption is 1/9th to that of methyl mercury which means 0.5/9 or .055mg/kg is absorbed through the intestines so the weekly dose comes out to be .055 x 7 =.385mg/kg bw/wk which is well below the even for the mark set for methyl mercury (the more dangerous one) .

4. Tissue distribution (As compared with methyl mercury, the total amount of HgS accumulated in the tissues is about one five-thousandth of methyl mercury) and dividing it by 5000 it comes out to be .385/5000 =.00007mg/kg bw/wk. Can it be toxic!!! This is the difference between the thinking pattern of ancient scholars and western scientists.

According to the criteria of the WHO the weekly dose of mercury that can be tolerated by the body is estimated and the United Kingdom’s Food Standards Agency (FSA) uses the safety standard applied by the World Health Organization (WHO) — called the Provisional Tolerable Weekly Intake (PTWI) — that allows 3.3 micrograms of methyl mercury per kilogram of body weight a week (ug/kg bw/week) for the general population and 1.6 micrograms of methyl mercury per kilogram of body weight (ug/kg bw/week) for pregnant and nursing women.

Where as in U.S FDA /EPA reference dose is 0.7 micrograms per kg of body weight per week. (Note: the EPA reference dose provides a ten-fold safety factor.

5. It therefore suggests that the amount taken in with 2 to 3 pills is well below then WHO tolerance boundary for the maximum weekly dose.

There is limited laboratory evidence suggesting that several dietary components might reduce (e.g. selenium, vitamin E, omega-3 fatty acids) or enhance (e.g. alcohol) mercury’s toxicity for some endpoints.

Now consider the strict regime to be followed along with mercurial preparations beside the fact that it is almost always invariably combined with sulphur which is the advice given by noted nutritionists (It will be important to have a high protein diet as the sulfur bearing amino acids in the protein will greatly facilitate detoxification) …. Mercury Detox Diet By Joseph Mercola, MD

6. Inorganic mercury compounds also do not move as easily from the blood of a pregnant woman to her developing child.

The question which should arise is that whether the herbs and Metals (mind you not only metals) used according to Ayurvedic principles does any harm to the human body if prescribed by an Ayurvedic doctor or more precisely Vaidya. ( and not when taken by the recommendation of a good friend or a claim by a pharmaceutical company)

The answer is Simple and one word -  NO.

Ayurveda has given supreme significance to the human body and even ascribed special position to god in the human body, which signifies the fact that how precious we are. Ayurveda probably is the only science which says Purshm Purshm Vikshym (Ch.S).which means characters of one person is different from the other (thoughts working style food habits etc) or in simple words No two human beings on this earth are same., so unlike allopathic, Ayurvedic doctor will prescribe different medicine to the persons suffering from the same disease based on their individual Prakruti (nature), Vikruti (Disease), Dosha -  dushya sammurchana (gradation of disease process) and Sroto-dushti (tissues involved) and that to with proper Anupan (vehicle for medicine) along with Patya – Apathya (Do’s and Dont’s for diet) details.

These two are different sciences devoted to the welfare of humans but with different principles, so the rule which apply to one does not apply to the other at all.

e.g. Heavy Metals  as popularly explained metals with specific gravity greater than 4 gm/cm which means when they are put on to the water they will settle at the bottom. But going by the tests for bhasmas for the final approval to use on the human beings must have following three qualities

1) They should float on water (what happened to the gravity!)
2) They should be able to take the weight of a rice grain. (More weight bearing must be a heart change for the metals)
3) They should have microfiness to fit into the lines of the hand and should not glitter.

So if the bhasmas have the same harmful properties as that of the metals how come it has lost all his physical properties and acquired new ones?

Well there are few explanations and theories to it but no facts to explain it perfectly.

Mercury and other metals become toxic only when they exceed a tolerable safe level.

If billions of people can exist without toxic symptoms at a tolerably low level of heavy metals, and if that has been the case as long as mankind has existed on the earth, it is highly misleading to tell patients they have “heavy metal toxicity” .

Again, none of this excuses herbal product manufacturers from stringent quality control standards; it’s just that we should put health risks in their proper perspective. In summary, I am not trumping up medicine safety issues relative to mercury in Ayurvedic medicine. I have simply reacted to the scientific community and regulatory agencies published findings that have alerted consumers to the need for caution and education so they make informed personal decisions as to their medicinal choices. My goal is to assist them to continue deriving the maximum health benefit from ancient Ayurveda with the confidence that they can do so safely.

Source: http://www.boloji.com/ayurveda/av053.htm

by Dr. Bhavna Joshi, MD

Triphala :
How It Works

Bottom Line: The anticancer effect of Triphala has not been confirmed in humans.

Triphala is an herbal formulation used in the Indian medicinal system of Ayurveda for the treatment of various ailments. It consists of three medicinal plants: Emblica officinalis, Terminalia chebula, and Terminalia belerica. It is used for anemia, jaundice, constipation, asthma, fever, chronic ulcers, inflammation, obesity and to strengthen the immune system against infections such as pneumonia, tuberculosis, and AIDS. Triphala was shown to have beneficial effects in studies done in laboratory and in animals. However human data are lacking.

Purported Uses

• To treat Infections. Studies done in mice showed that Triphala can reduce infections. No studies have been done in humans.
• To decrease high levels of cholesterol. Triphala was shown to reduce cholesterol levels in rats with high cholesterol. However, this has not been studied in humans.
• To strengthen the immune system. Studies in rats have shown that Triphala can improve immune function but human data are lacking.

Research Evidence

Several laboratory studies have shown that Triphala has beneficial effects. However, it has not been studied in humans.

Side Effects

Intestinal gas Stomach upset Diarrhea.

Constituents

Amla (Emblica officinalis) Myrobalan (Terminalia chebula) Belleric Myrobalan (Terminalia belerica).

Mechanism of Action

The exact mechanism of action is not known although the polyphenols and flavonoids are thought to be responsible for many of Triphala’s effects. Gallic acid, a major polyphenol in Triphala, has antioxidant property. Triphala also increased the reactive oxygen species (ROS) in breast cancer cells (MCF-7 and T-47D), resulting in apoptosis. Terminalia chebula, one of the components of Triphala, was shown to be a potent hyaluronidase and collagenase inhibitor that prevented degradation of cartilage. Triphala also protected mice from radiation-induced mortality. Oral administration of Triphala enhanced the immune functions in rats.

Adverse Reactions

Intestinal gas, stomach upset, diarrhea.

Ashwagandha : How It Works

Bottom Line: While ashwagandha has shown an ability to hinder the growth of cancer cells in laboratory tests and enhance radiation therapy in animals, it is unknown if these effects can be replicated in humans.

A popular Ayurvedic medicinal substance derived from the root and berry of the plant. Ashwagandha contains numerous biologically active components. It is thought that some of these components can influence potent hormone-like substances that cause arthritis inflammation. Extracts of the root also increase the number of red and white blood cells and platelets in the blood. Ashwagandha has been shown to relax the central nervous system in animals. Studies in laboratories have shown that extracts of ashwagandha kill some cancer cells and enhance some immune cells. It is thought that the structure of ashwagandha extracts may damage the cancer cells ability to generate the energy it needs to reproduce. Ashwagandha also reduces the level of glutathione, an antioxidant, in tumor cells which may enhance the effects of radiation therapy against those cells. Studies in animals have demonstrated possible toxicity, however comparable effects have not been observed in humans.

Purported Uses

To treat cancer

While ashwagandha has shown promise in animal and laboratory studies, few trials have demonstrated an effect in humans.

To treat diabetes
No scientific evidence supports this use.

To treat epilepsy
No scientific evidence supports this use.

To reduce fatigue
Ashwagandha has been shown to increase blood cell counts in the lab, however it is unclear if this will reduce fatigue in humans.

To treat digestive disorders
No scientific evidence supports this use.

To maintain health
Ashwagandha has antioxidant properties in lab tests, however it is unclear if it will have any effect on humans.

To reduce pain
Ashwagandha has been shown to have a tranquilizing effect in animals. It is unclear if this will reduce pain in humans.

To treat rheumatoid arthritis
A clinical trial showed effectiveness of a herbomineral formula containing ashwagandha. To what extent ashwagandha played a role in the reduction in pain severity and disability is unclear.

As a sedative
Ashwagandha has been shown to have a tranquilizing effect in animals. It is unclear if it has a similar effect in humans.

To treat skin infections
No scientific evidence supports this use.

To relieve stress
Ashwagandha has been shown to have a tranquilizing effect in animals. It is unclear if it has a similar effect in humans.

Research Evidence

Arthritis Pain:

Forty-two volunteers with osteoarthritis participated in a trial of a herbomineral formula containing ashwagandha. Volunteers were randomly assigned to receive either a combination of herbs and minerals or placebo for three months. After a fifteen-day washout period, treatments were reversed. Volunteers in the treatment group reported significant drops in pain severity and disability score with few side effects. Because a combination of herbs was used, it is unclear if ashwagandha played an important role in the results.

Warnings: Do Not Take If

You are pregnant.
(Ashwagandha  may induce abortion.)
You are You are taking sedatives.
(Ashwagandha may increase sedative effects.)

Scientific Name : Withania somnifera.
Family: Solanaceae

Constituents
Alkanoids: isopelletierine, anaferine
Steroidal lactones: withanolides, withaferins
Saponins: sitoindoside VII and VIII Iron

Mechanism of Action

Alkaloids, steroidal lactones, saponins and withanolides are thought to be the biologically active components. Studies have pointed to cyclooxygenase inhibition as the cause of the herb’s anti-arthritis properties. Ashwagandha’s anti-inflammatory effects were comparable to hydrocortisone sodium succinate in rats. The root extract of the herb produced significant increases in hemoglobin concentration, red blood cell count, white blood cell count and platelet count. Ashwagandha has been shown to exhibit antioxidant effects in the brain and to have a tranquilizing effect on the central nervous system in animals. In vitro, isolates from the root of the plant have cytotoxic properties against H-460, HCT-116, SF-268 and MCF-7 cell lines. Ashwagandha increase cytotoxic T lymphocyte production. Other studies show ashwagandha’s cytotoxicity is related to its structure and that it enhances ATPase and inhibits succinate dehydrogenase activity, impairing oxidative phosphorylation. In animal studies, ashwagandha can increase the effects of radiation therapy and inhibits tumor growth. The herb also reduces tumor GSH levels which may contribute to the enhancement of radiation response. Ashwagandha can reverse paclitaxel induced neutropenia in mice. Significant toxicity was observed at high doses in animal studies, however, toxicity studies in humans are limited.

Source: http://www.boloji.com/ayurveda/av072.htm